Abstract 1068: High Level of Plasma Endothlin-1 Predicts Development of Hypertension in Normotensive Subjects
Background: Endothelin-1 (ET-1) is a potent vasoconstrictor derived from the endothelium. However, most large scale cross-sectional studies in humans have indicated no relationship between plasma ET-1 levels and hypertension. Therefore, it is unknown whether ET-1 has any causal role in hypertension. The present study was designed to determine whether high plasma ET-1 levels predict the development of hypertension.
Methods: A total of 1,492 subjects received a health examination in the Japanese cohort of Seven Countries Study in 1999. At that time we examined blood pressure, body mass index (BMI) and blood chemistries. Data on fasting ET-1 were obtained in 1,451 individuals. Seven years later 1,261 subjects (494 males and 767 females) were re-examined(follow-up rate=87%).
Results: Of 814 normotensives (blood pressure <140/90 mmHg without anti-hypertensive medications) at baseline, 222 subjects developed hypertension (blood pressure ≥140/90 mmHg and/or use of antihypertensive medications). We divided the baseline plasma ET-1 levels into quartiles. The odds ratio of the development of hypertension after 7 years was 1.81 (95% CI, 1.08–3.02) in the highest quartile vs. the lowest quartile for ET-1 levels after adjustments for confounding factors.
Conclusions: A high level of plasma ET-1 predicted the development of hypertension after seven years in normotensive subjects. This study is the first to demonstrate a causal relationship between plasma ET-1 and the development of hypertension.