Abstract 1018: The Relationship Between the Ratio of Serum Eicosapentaenoic Acid(EPA) to Arachidonic Acid(AA) With Major Adverse Cardiac Events in Patients Undergoing Elective Percutaneous Coronary Intervention
Backgrounds: Evidence that n-3 fatty acids have anti-sclerotic effects has been accumulating. Especially, some reports showed that the ratio of serum EPA to AA (EPA/AA) might be associated with major cardiac events. But the impact of EPA/AA on secondary prevention of coronary events was not fully evaluated yet. This study examined relationship between EPA/AA and coronary events in patients received elective percutaneous coronary intervention (PCI).
Methods: A total of 284 consecutive patients with stable angina received elective PCI were enrolled in this study. Serum EPA and AA data were collected on admission. We divided patients into two groups evenly according to EPA/AA; lower EPA/AA group (group A, n=142), higher EPA/AA group (group B, n=142) and examined the relationship with major adverse cardiac event (MACE) including cardiac death, acute coronary syndrome, CABG, and non-fatal coronary events between two groups. Kaplan-Meier method and logrank test were chosen for statistical analysis.
Results: Baseline characteristics including gender, hypertension, hyperlipidemia, diabetes mellitus, chronic kidney disease, and smoking were not significant difference between two groups. Mean follow up time was 537+-126 days. Group A had significant higher incidence of MACE than group B (p=0.015, Fig 1⇓). The ratio of EPA to AA had no significant correlation to other coronary risk factors, indicating it is an independent risk factor.
Conclusions: Despite short follow up duration, EPA/AA had strong relationship with incidence of MACE in patients undergoing elective PCI.