Abstract 897: Leptin and Soluble Leptin Receptor Levels in Plasma and Risk of Type 2 Diabetes in US Women: A Prospective Study
Background: The relationship between plasma levels of leptin and soluble leptin receptor (sOB-R) and risk of type 2 diabetes remains to be elucidated.
Objective: To prospectively examine plasma levels of leptin and sOB-R in relation to type 2 diabetes.
Design and Setting: The Nurses’ Health Study.
Participants: Of 32,826 participants who provided blood samples during 1989 –1990, 1,054 incident cases of type 2 diabetes were identified and confirmed during 1990 –2004 and 1,254 matched controls were selected.
Measurements: Plasma leptin and sOB-R levels.
Results: After multivariate adjustment for body mass index (BMI) and other diabetes risk factors, sOB-R levels were significantly associated with a lower risk of type 2 diabetes. In comparison to women in the lowest quintile, the odds ratios (95% CI) of developing type 2 diabetes were 0.73 (0.55, 0.96), 0.51 (0.38, 0.68), 0.42 (0.31, 0.57), and 0.39 (0.28, 0.54; P for trend <0.0001) for women in the 2nd to 5th quintiles of sOB-R levels, respectively. After adjusting for BMI and other covariates, plasma leptin levels were not significantly associated with the risk of type 2 diabetes: The odds ratio (95% CI) was 0.82 (0.62, 1.10; P for trend=0.46) comparing the highest with the lowest quintile of leptin levels. sOB-R levels were consistently associated with a decreased risk of type 2 diabetes at various levels of leptin or high-molecular-weight (HMW) adiponectin. Women who were in the highest tertiles of both sOB-R and HMW adiponectin had the lowest odds of developing type 2 diabetes; the OR (95% CI) was 0.13 (0.09, 0.20) in comparison to women in the lowest tertiles of these two markers.
Limitation: Residual confounding by adiposity may partially explain the observed associations.
Conclusion: These data suggest a strong inverse association between plasma sOB-R levels and risk of type 2 diabetes, independent of BMI, leptin, and adiponectin levels.