Abstract 880: Early Impairment on Heart Rate Variability in Offspring of Diabetic Parents: Role of Physically Active Life
The objective of the present study was to compare the cardiovascular autonomic modulation between sedentary or physically active offspring of type II diabetic or normoglicemic parents. Young healthy males subjects were assigned into 4 groups: sedentary (CS, n=8) or physically active (CPA, n=8) offspring of normoglicemic parents, sedentary (ODS, n=9) or physically active (ODPA, n=6) offspring of diabetic parents. The subjects were submitted to systolic (SAP) and diastolic (DAP) arterial pressure measurements through auscultatory method and to a continuous recording of RR interval during 30 minutes using a Polar S810 at rest. The cardiac autonomic modulation was evaluated in the time and frequency domains (FFT). Subjects presented normal values of body mass index and glicemia. SAP and DAP were similar between groups. Resting bradicardia was observed in physically active subjects (CFA:64±3 and ODPA:68±4bpm) as compared to sedentary subjects (CS:71±3 and ODS:75±3bpm). The standard deviation of RR interval and the R-R variance were lower in ODS group (52±3ms and 2932±894ms2) when compared to CS (91±7ms and 9604±395ms2), CPA (124±11ms and 14866±3018ms2) and ODPA groups (99±8ms and 10458±1843ms2). Moreover, the CPA subjects presented higher values of these parameters in relation to CS and ODPA subjects. The low-frequency band of RR interval (LF) was lower in CS (43±5%), CPA (44±2%) and ODPA groups (40±4%) as compared to ODS group (76±4%). Considering the high-frequency band of RR interval (HF), the ODS group (24±4%) presented reduced values in relation to CS (43±5%), CPA (44±4%) and ODPA groups (40±4%). The sympathetic-vagal balance (LF/HF) was lower in CS (1.69±0.14), CPA (1.35±0.10) and ODPA subjects (1.57±0.28) when compared to ODS subjects (4±0.78). In this sense, we conclude that normotensive offspring of diabetic parents seem to have dysfunction of the cardiac autonomic modulation at rest characterized for a cardiac sympathetic overactivity. Moreover, the results showed that the early autonomic dysfunction observed in this genetically predisposed population can be reverted through changes in the lifestyle, as increasing the physical activity.
Financial support: FAPESP (08/10189–5, 08/51868–2, 07/57595–5).