Abstract 842: Pericardial Fat and Cardiovascular Disease Risk Factors: The Jackson Heart Study
Background - Pericardial adipose tissue (PAT), a regional fat depot, is associated with an unfavorable metabolic and cardiovascular risk factor profile. Whether higher levels of PAT can provide one of links between obesity and cardiometabolic risk factors has not been fully explored in African American populations.
Methods and Results - 1,414 African Americans (35% men; mean age 55±11, range 21– 84 years) drawn from the Jackson Heart Study (JHS) underwent multi-detector computed tomography assessment of abdominal visceral adipose tissue (VAT) and PAT between 2006 and 2008. Cardiometabolic risk factors were examined in relationship to increments of PAT and VAT after multivariable adjustment among both men and women. PAT (per 1-standard deviation increase) was significantly associated more adverse levels of triglycerides, high-density lipoprotein and C-reactive protein in both men and women, with increases in fasting plasma glucose in women, and with increases in systolic blood pressure in men. PAT was also associated with increased odds ratio (OR) of metabolic syndrome (OR 2.1), hypertension (OR 1.7) and diabetes (OR 1.5, all p-values <0.001) in women; similar findings were noted in men as well. However, after further adjustment for body mass index (BMI) and VAT, these relationships remained significant only in women.
Conclusion - PAT is correlated with most cardiometabolic risk factors in the JHS cohort, and these observations persist after accounting for other measures of adiposity in women. The results suggest that PAT, like VAT, is an important correlate of cardiovascular disease risk factors.