Abstract 836: Body Fat Related to Clustering of Risk Factors for CVD in Children
Introduction. Obesity is associated with increased risk of cardiovascular disease in adults and less favourable CVD risk factor status in children. These relationships have not been extensively studied in young subjects with the use of objective methods.
Hypothesis. We assessed the hypothesis if body fat is related to clustering of risk factors for CVD in children aged 8 to 11 years.
Methods. Cross-sectional study of 170 (92 boys and 78 girls) children aged 8 –11 years, recruited from a population-based cohort. Total fat mass was measured by Dual-energy x-ray absorptiometry and expressed as percentage of total body mass (BF%). Maximal oxygen uptake (VO2PEAK) was assessed by indirect calorimetry during maximal exercise test. Blood was sampled and blood pressure (BP), and resting heart rate (HR) were measured. Echocardiography, 2-dimensional guided M-mode, was performed in accordance with ASE guidelines and left ventricular mass (LVM) was calculated. Maturity evaluated according to Tanner. Z-scores (Value for the individual-mean value for group)/SD were calculated. Sum of z-scores for triglycerides (TG) and lipoprotein concentrations, systolic and diastolic BP, HR, LVM, and -VO2PEAK were calculated in boys and girls, separately, and used as an indices of clustered risk.
Results. Mean BF% was 18.8±8.9% (range 6.2– 44.7). Pearson correlation between BF% versus indices of clustered risk were for boys (r=0.49, P<0.05) and for girls (r=0.57, P<0.05). Boys and girls were divided according to tertiles of BF%. One-way ANOVA analysis indicated highly significant differences in sum of z-scores between tertiles of BF% in boys (P=<0.001), and in girls (P=<0.001).
Conclusion. Findings from this population-based cohort of young children shows that BF% was associated with a clustering of cardiovascular risk factors.