Abstract 833: CARDIA: Prevalence and Socio-demographic Predictors of Pulmonary Hypertension in Young Adults
Objective: Risk factors for pulmonary hypertension (PH) are poorly understood. The aim of current study is to describe the prevalence, socio-demographic and clinical predictors of pulmonary hypertension in young adults.
Methods: Coronary Artery Risk Development in Young Adults (CARDIA) study is a longitudinal study of young adults to assess the risk factors for cardiovascular disease. Limited access dataset provided by the National Heart, Lung, and Blood Institute was analyzed. Doppler pulmonary artery acceleration time (DPAAT) was used to assess PH (Echocardiographic data from year five). Socio-demographic characteristics including age, race, gender, body mass index (BMI), smoking status, alcohol intake, physical activity (calculated based on a questionnaire and expressed in exercise units) and self reported clinical variables (hypertension, diabetes mellitus, cholesterol problem, heart problems and kidney problems) were assessed.
Results: Study subjects with no missing data retained in year five were included in current analysis, 3986 African American and Caucasian males and females aged 23–35 years. The prevalence of severe PH (DPAAT ≤70 msec) and mild to moderate PH (DPAAT=109.9 –70.01 msec) was 1.1% and 14%, respectively. Multivariate analysis using linear regression revealed that age (β= −0.33, p=0.011), Hispanic race (β= −2.41, p=0.013), male gender (β= −7.97, p<0.0001), overweight status defined as BMI 25–29.9 kg/m2 (β=−6.85, P<0.0001), obesity defined as BMI β30 kg/m2 (β=−17.48, P=0.0001), physical activity (β=0.004, P=0.04), and current smoking (β=−4.1, P=0.0001) were statistically significant variables predicting PH. None of the self reported clinical variables were significantly related to PH. Multivariate analysis using ordinal logistic regression showed that gender, physical activity, body mass index, current smoking status were statistically significant predictors of PH.
Conclusions: In young adults, the prevalence of pulmonary hypertension estimated by doppler pulmonary artery acceleration time is high (15%). Factors predicting pulmonary hypertension include age, obesity, male gender, smoking, and low physical activity.