Abstract 831: Associations Between Inter-adventitial Diameters of the Common Carotid Artery, Cardiovascular Risk Factors, Carotid Intima-media Thickness and Left Ventricular Mass: The Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Inter-adventitial diameter (IAD) is associated with atherosclerosis and hypertension. It is not clear if sub-clinical atherosclerosis, measured as intima-media thickness (IMT), and left ventricular hypertrophy, measured as left ventricular mass (LV mass), are associated with IAD after accounting for traditional cardiovascular risk factors.
Materials and Methods: IAD and IMT were measured on participants of the Multi-Ethnic Study of Atherosclerosis IMT progression study who had ultrasound imaging of the right common carotid artery (CCA). A total of 5641 (mean age 61.9 years) participants (52% female, with 26% African-Americans, 12% Chinese 12%, 22% Hispanic 22% and 40% Caucasian (40%). LV mass was measured by magnetic resonance imaging. Multivariable linear regression was used with IAD as the outcome and adjustment for risk factors, including height, weight, IMT and LV mass.
Results: Traditional cardiovascular risk factors were significantly associated with IAD. After adjustment for risk factors, a one mm difference in IMT was associated with a 1.802 mm (95% CI: 1.553, 2.051) higher mean IAD. A one gm difference in LV mass was associated with a 0.006 mm (95% CI: 0.005, 0.007) higher mean IAD. LV mass and IMT were independently associated with IAD. These associations were slightly different for men, women and different ethnic groups.
Conclusions: Inter-adventitial diameters are associated with traditional cardiovascular risk factors as well as with measures of subclinical atherosclerosis and left ventricular mass. Given that LV mass remains independently associated with IAD after controlling for subclinical atherosclerosis as measured by IMT, IAD might have additional predictive value for cardiovascular outcomes.