Abstract 829: Prevalence of Cardiac Dysfunction in the Population: Results From the Community-Based Gutenberg-Heart Study
Background: Epidemiological data about the prevalence of asymptomatic and symptomatic, systolic and diastolic cardiac dysfunction based on current echocardiographic techniques is still scarce. However, all of these disorders are associated with an increase of mortality.
Objectives: To measure the distribution of subtypes of cardiac dysfunction in the community by echocardiography and evaluate the associations to cardiovascular risk factors.
Methods: Data from 5.000 participants of the age- and gender-stratified, community-based Gutenberg-Heart Study, examined from 2007 to 2008 have been analyzed. Cardiovascular risk factors, clinical parameters and echocardiograms were assessed by standardized methods with detailed quality control.
Results: The sample comprised 2540 men and 2460 women, aged 35 to 74 years (average age: 55.5 ±11.0 years). The overall prevalence of cardiac dysfunction was 22.2%; diastolic disturbances were present in 21.1%, systolic disturbances in 1.8%. Diastolic dysfunction (DD) was considerably more frequent (16.5% vs. 1.2%) than systolic dysfunction (SD), and diastolic heart failure (DHF) than systolic heart failure (SHF; 4.6% vs. 0.6%). The most common subtypes were the isolated diastolic disorders: diastolic dysfunction with preserved ejection fraction (16.2%) and heart failure with preserved ejection fraction (4.3%). All subtypes of diastolic disturbances showed a correlation to age, whereas only SHF did for systolic disturbances. Systolic compared to diastolic disturbances were more often symptomatic (34.2% vs. 21.8%). Reported medicated vs. not-medicated heart failure was less frequent in DHF (13.9%) than in SHF (44.8%). In multivariate logistic regression models, all cardiac dysfunctions showed associations to body mass index, prevalent diabetes mellitus, blood pressure and lipids. Systolic dysfunction was associated with male, whereas diastolic dysfunction with female gender.
Conclusion: Cardiac dysfunction is frequently present in the community. Diastolic dysfunction and heart failure with preserved ejection fraction represent the majority of cardiac dysfunctions. Systolic disorders are more often symptomatic and systolic heart failure is more often treated by medication.