Abstract 820: Association of Increased Plasma Adipocyte Fatty Acid-binding Protein With Coronary Artery Disease in Men
Background: Adipocyte fatty acid-binding protein (A-FABP) has been shown to effect on insulin resistance, lipid metabolism, and atherosclerosis in animal. We investigated whether an increased in plasma A-FABP level can be independently associated with the prevalence of coronary artery disease (CAD) in human subjects.
Methods: The consecutive 111 male patients (mean age; 67±13 years) were enrolled from inpatients undergoing CAG. Age-matched 111 male subjects having no evidence of CAD were served as controls. Plasma A-FABP levels were measured by enzyme-linked immunosorbent assays.
Results: Plasma A-FABP levels in the CAD patients were significantly higher than those in the control subjects (16.5 (12.1 to 21.8) vs. 21.5 (15.5 to 28.3) ng/mL, median (IQR) p<0.001). Multiple logistic regression analysis including plasma A-FABP level, diabetes, dyslipidemia, smoking, and body mass index revealed that an increased plasma A-FABP level was independently associated with CAD (p=0.003). When all subjects were categorized into quartiles based on the plasma A-FABP, the multiple adjusted odds ratios of CAD in the second, third, forth quartiles were 0.700 (95% confidence interval [CI], 0.281 to 1.748, P=0.445), 1.967 (95%CI, 0.798 to 4.845, p=0.141), 2.928 (95%CI, 1.077 to 7.961, p=0.035), respectively.
Conclusions: Male patients with an increased plasma A-FABP (≥25.2 ng/mL) had a significant 3-fold increase in CAD prevalence, independent of well-known CAD risk factors.