Abstract 812: Dietary Sodium Intake Influences Carotid Structure and Hemodynamics in Hypertensive Subjects
Background: We assessed the hypothesis that dietary sodium intake might influence the structure and hemodynamics of carotid arteries in hypertensive subjects.
Methods: One hundred twenty one patients (55% women; 58±1 years) were evaluated by clinical history, physical examination, anthropometry, analysis of hemodynamic, inflammatory and metabolic parameters and carotid ultrasound examination. Daily sodium intake (DSI) was measured using previously validated methodology and consisted of collecting a 24 hour recall, discretionary salt used in the household and a food frequency questionnaire.
Results: The studied sample had a DSI of 5.5±0.3 g/day. Univariate analysis showed that DSI correlated with common carotid artery (CCA) systolic and diastolic diameter (r=0.36 and r=0.34; both p<0.001), peak and mean circumferential tension (r=0.44 and r=39; both p<0.001), Young’s elastic modulus (r=0.40, p<0.001), intima-media thickness (r=0.19, p<0.05) and with internal carotid artery resistivity index (r=0.20; p<0.05). Conversely, DSI showed no significant correlation with common carotid artery compliance and stiffness index. Multivariate analyses adjusted for age, sex, body mass index, blood pressure, smoking, cardiac output, urinary sodium excretion and antihypertensive medications showed that DSI was associated with CCA diameter (p<0.001), circumferential wall tension (p<0.01) and Young’s Elastic Modulus (p<0.01), but was not independently related to CCA intima-media thickness and internal carotid artery resistivity index.
Conclusion: These results indicate that sodium intake is an independent predictor of reduced elasticity, increased luminal diameter and higher local hemodynamic load in carotid arteries of hypertensive subjects.