Abstract 810: Long-term Adherence to the Traditional Mediterranean Diet is Associated With Improved Biventricular Systolic Function, in Chronic Heart Failure Patients
Background: Systolic function of both ventricles has been recognized to play a crucial role in the progression of heart failure. However, data about the role of dietary habits on systolic dysfunction are lacking in the literature.
Methods: During 2007, 184 male (63±13 years) and 34 female (65±13 years) chronic heart failure patients who consecutively visited the Heart Failure Unit of our Institution, were enrolled. Left ventricular systolic function was evaluated through echocardiography. The pulsed tissue Doppler imaging (TDI) of the systolic and diastolic function of mitral annulus was characterized by the systolic wave Smv, and the diastolic waves: Emv and Amv. Left atrial (LA) ejection fraction was calculated using the equation LASV-LADV/LASV; where LASV and LADV are left atrial systolic and diastolic volume, respectively. Dietary habits were assessed through a detailed FFQ, and adherence to the Mediterranean diet was evaluated using a special score proposed by Trichopoulou and colleagues (i.e., the MDS, range 0 –9).
Results: Mean diet score was 4.25±2.4; suggesting poor adherence to the traditional dietary pattern, while 25% of the patients scored >6 in the MDS, defining a healthy eating group. All patients reported long-term adherence to this traditional pattern. Multiple linear regression analysis, after adjusting for age, gender, clinical and biological characteristics of the patients revealed a positive association between MDS and Smv (b±SE: 0.62±0.08, p=0.001), Stv (b±SE: 0.25±0.09, p=0.07), left ventricular ejection fraction (b±SE: 0.58±0.30, p=0.05), and LA ejection fraction (b±SE: 2.20±0.67, p=0.001). Moreover, higher MDS values were associated with higher Emv (b±SE: 0.69±0.17, p=0.001), and Amv (b±SE: 0.42±0.20, p=0.03).
Conclusions: This work demonstrated for the first time in the literature another potential protective mechanism of Mediterranean diet on secondary prevention of cardiovascular disease and mainly on the progression of heart failure, through the improvement of systolic function. The latter finding was independent from various potential confounders and emerge the need for further actions from public health care authorities in primary and secondary prevention.