Abstract 728: Right Ventricular Global Longitudinal Systolic and Diastolic Function is Diminished in Patients With Pulmonary Arterial Hypertension: A 2D Ultrasound Speckle Tracking Imaging Study
Background and objectives: The assessment of right ventricular (RV) function in patients with pulmonary arterial hypertension (PAH) is a challenge for conventional 2D and Doppler electrocardiography. Recently, strain and strain rate by 2D speckle tracking imaging (STI) imaging were used to measure RV regional and global function which obviate the need for RV geometry assumption.
Methods A total of 42 patients with PAH and 31 healthy controls were enrolled in this study. Based on systolic pulmonary arterial pressures, PAH were divided into mild PAH Group (n=17), moderate Group (n=15) and severe Group (n=10). RV global longitudinal peak systolic strain (GLS), strain rate (GLSRS), early diastolic strain rate (GLSRe) and late diastolic strain rate (GLSRa) were measured by STI from the apical 4-chamber views.
Results RV global longitudinal systolic and diastolic function were significantly impaired in patients with mild, moderate and severe PAH groups as compared to controls (P <0.05 for all). RV GLS were altered the most in patients with the severe PAH as compared with mild PAH (0.05 for all). Pulmonary vascular resistance and systolic PA pressure correlated with RV global longitudinal systolic function (r = −0.466~−0.549, r = −0.403~−0.425, respectively, P<0.05 for both). There were good correlations between tricuspid annular systolic peak velocity and RV GLS, GLSRs in PAH (r = 0.556~0.585, P<0.001).
Conclusions Our data suggest that it is feasible to assess RV global longitudinal function by STI. RV global function significantly decreased in patients with PAH. Further study is warranted to establish the prognostic values of these new measures in PAH.