Abstract 722: Noninvasive Assessment of Carotid Arterial Mechanics in Marfan Syndrome Using Velocity Vector Imaging
Background: Marfan syndrome (MFS) is a multi-systemic connective tissue disorder associated with mutation of fibrillin-1, the main component of microfibrils. Fibrilin-1 gene mutation could affect the property of carotid arterial wall. We sought to investigate carotid arterial mechanics using velocity vector imaging (VVI) in patients with MFS.
Method: Thirty-eight MFS patients (23 males, mean age 39±10) and 38 age, gender and body surface area-matched controls were studied. Transverse images of both common carotid arteries (CCA) distal to bifurcation were obtained and divided into 6 segments. The peak radial velocity, circumferential strain and strain rate of 6 segments were analyzed using VVI. The time to peak radial velocity (Ts), circumferential strain (Tst) and stain rate (Tsr) of 6 segments were calculated. Intima-medial thickness (IMT) was also measured.
Results: IMT of both CCA was comparable between two groups. Peak radial velocities, circumferential stain and strain rates were significantly higher in patients with MFS (p=0.004; p=0.059; p=0.029). However, SD of Ts and Tsr were significantly larger in patients with MFS, suggesting heterogenous local arterial expansion (p=0.047 and p=0.040)(Figure⇓).
Conclusions: In patients with MFS, carotid artery showed exaggerated but dyssynchronous arterial expansion during systole when compared with healthy controls. Arterial assessment using VVI may represent a new method for quantifying vascular alteration associated with MFS noninvasively.