Abstract 559: Survival From Cardiovascular Events as Predicated by Carotid (Common Carotid Artery) Intima-media Thickness and Doppler Values in Ischaemic Chinese Patients Requiring Coronary Angiogram
Background: Carotid intima-media thickness (cIMT) of the common carotid artery may be correlated to the presence of coronary artery disease. However, the role of the cIMT and Doppler findings in predicting subsequent cardiovascular (CVS) events has not been established. The aim of this study is to investigate the predictive value.
Methods: 212 consecutive Chinese patients underwent clinically driven coronary angiogram were evaluated. Carotid parameters (cIMT, peak systolic velocity (PSV) & end diastolic velocity, at the bulb, internal and common carotid artery, on both sides) were analyzed using the IE33 auto-detection program. Patients were followed up and monitored for the occurrence of the primary composite end-point (PCEP), defined as all cardiovascular deaths, non-fatal MI, stroke, CHF, ACS or arrhythmias requiring hospitalization or intervention.
Results: To date, the mean follow-up time was 534±234 days. The primary composite end-point was reached in 25 subjects (11.8%). The right common cIMT was shown to be a predictor for critical coronary stenosis requiring PCI (area under ROC curve=0.626, p=0.001). cIMT < 0.8mm was associated with a better survival (log rank test, p= 0.029). Univariate analysis, a right common cIMT of <0.8mm, the right common carotid PSV and the waist circumference were independent predictors for the PCEP. Cox proportional hazards model, adjusted for age showed the right common carotid PSV was the only independent predictor for the PCEP (HR: 0.963, 95% CI: 0.939 to 0.987, p=0.002). Similar correlations were not observed with the Overall (left & right) cITM or the left cIMT in this study.
Conclusion: The right common carotid PSV & the right common cIMT ≥0.8mm are shown to predict the CVS survival in this study. The latter also strongly correlates with the presence of critical coronary stenosis requiring intervention.