Abstract 540: Diastolic Heart Function Assessed With Multidetector Row Computed Tomography: Feasibility Study in Comparison With Tissue Doppler Imaging
Objectives Although 64-multidetector row computed tomography (MDCT) has been used commonly for evaluation of coronary artery disease, its feasibility to evaluate diastolic function has not been studied. Accordingly, this study evaluated the feasibility of 64-MDCT for assessment of diastolic function as compared to 2D echocardiography using tissue Doppler imaging (TDI).
Methods Sixty patients with 64-MDCT and 2D echocardiography using TDI were enrolled. Diastolic function was evaluated with early (E) and late (A) peak transmitral velocity and peak mitral septal tissue velocity (Ea) (Figure 1⇓). LV volumes were calculated for 20 phases per cardiac cycle and changes in LV volumes between 2 phases were plotted in a transmitral flow curve (left lower curve). Early and late peak transmitral flow were derived. To allow comparison with echocardiography, E and A were calculated by dividing early and late peak transmitral flow (mL/s) by the mitral valve area (mm2). Mitral valve areas were measured at the corresponding phase. LV length was calculated for 20 phases and the maximal change in LV length between 2 cardiac phases was used to calculate Ea (right lower curve).
Results Good correlations were observed between 64-MDCT and echocardiography for E (r = 0.72, p < 0.01), E/A (r = 0.85, p<0.01) and Ea (r = 0.75, p<0.01). Moreover, good agreement was found for estimation of LV filling pressures (E/Ea) (r = 0.76, p<0.01) between both techniques.
Conclusion 64-MDCT imaging is a feasible technique to evaluate diastolic function. Combined assessment of transmitral velocity and mitral septal tissue velocity allows accurate evaluation of diastolic function as compared to echocardiography with TDI.