Abstract 523: Decreased Radial Function is Associated With Subtle Left Ventricular Remodeling in Type 2 Diabetes Mellitus
Background: Previous studies have suggested that reduced longitudinal myocardial function might be compensated by increased radial contractility in patients with type 2 diabetes mellitus (DM).
Aim: To evaluate left ventricular (LV) remodeling in type 2 DM according to radial function assessed by STI.
Methods: 234 asymptomatic type 2 DM patients with no sign or history of heart disease and normal conventional echo parameters were included. Mean radial strain (SR) was assessed by STI from short-axis view at the midventricular level. Mean longitudinal strain (SL) was calculated from the apical 2- and 4-chamber views. The population was divided into 3 groups according to SR value: group I = SR <45%(n = 101), group II = SR between 45 and 60% (n = 76) and group III = SR >60% (n = 57). Differences between groups were tested by ANOVA.
Results: Clinical, biological and echographic data are shown in table⇓. Age, body mass index (BMI), duration and severity of DM, systolic (sBP) and diastolic (dBP) blood pressure and LV mass index (LVMi) were similar between groups. Conventional systolic parameters (LVEF: LV ejection fraction and FS: fractional shortening) were also similar. However, a lower SR was associated with a significant increase in LV end-diastolic (LVEDD) and end-systolic (LVESD) diameters and a decreased SL.
Conclusion: These data suggest that an altered radial function might be an indicator of more advanced diabetic cardiomyopathy with altered systolic function and beginning of eccentric LV remodelling.