Abstract 487: Relationship Between Carotid Intima Media Thickness and Coronary Artery Calcium Progression in the Multi-ethnic Study of Atherosclerosis (MESA)
Background: The purpose of this investigation was to assess if increasing carotid intima-media thickness (CIMT) measurements are associated with coronary arterial calcification (CAC) progression, a disease state that is thought to be associated with an increased coronary risk.
Methods: MESA is a prospective cohort study of 6814 participants free of clinical cardiovascular disease at entry who underwent risk factor assessment and CAC testing at baseline (exam 1) and follow up (exam 2– 4) examinations. We assessed incident CAC, defined as detectable CAC at the follow-up exams among those free of CAC at baseline, and ii) absolute CAC score change among those with detectable CAC at baseline. The independent relation between increasing CIMT (quartiles as well as per SD increase) with CAC progression was assessed by relative risk (RR) regression (for incident CAC) using a generalized linear model and binomial error distribution adjusting for covariates. Among those with detectable CAC at baseline, multivariable adjusted median linear regression was employed. We excluded 767 individuals who did not undergo follow-up CAC testing. In addition, we excluded 159 individuals who did not have CIMT data at baseline.
Results: The final study population consisted of 5888 individuals (61 ±10 years, 47% males). In a mean follow-up period of 3.1 ±1.3 years, among 3019 (51%) individuals with no detectable CAC at baseline, 20% (n = 608) developed CAC. Table 1⇓ demonstrates that in demographic (model 1) and traditional risk factors (model 2) adjusted analyses, a higher CIMT is significantly associated with incident CAC, as well as with change in absolute CAC scores among those with CAC >0 at baseline.
Conclusion: Increasing CIMT measurements are associated with the initial occurrence of coronary arterial calcification in individuals with no calcium deposition at baseline as well as with CAC progression in individuals with a positive calcium score at baseline.