Abstract 480: In Subclinical Atherosclerosis and Cardiovascular Risk Factors, the US Still Leads but Western Europe is Rapidly Catching up
Atherosclerosis has become a global disease. Complications of clinical disease like myocardial infarction and stroke may vary still slightly per country. Therefore, it seems important to assess the extent and severity of quantitative subclinical atherosclerosis given the increase of disease complications in countries that adapt an American lifestyle. We compared in an asymptomatic population the incidence of major cardiovascular risk factors as well as quantitative sonographic carotid intima media thickness and plaque formation (IMTplus®) assessment in the US and Western Europe (WE; Netherlands, Belgium and Germany). Smoking behavior, total cholesterol values, blood pressure and body mass index well also measured. The distribution was made in accordance with standardized normal values for CIMT. (“A” being a value below 50, <0.700 mm; “B” being a value between 50 and 90, 0.700 – 0.850 mm; “C” being between 90 and 125, 0.851– 0.948 mm; “D” being 125 and 200, 0.948 –1.300 mm; “E” above 200, >1.300 mm; p means percentile Normal values derived from the Prevention Concepts database The US as compared to the WE showed an elevated LDL cholesterol (>110 mg/dl) of 39% vs. 28%, Blood pressure elevation (>130/80 mm Hg) 35% vs. 41%, smoking 18% vs. 26% and Body Mass Index (BMI) elevation (>30m/kg2 ) 36% vs. 25% Subclinical atherosclerosis is more extensive in the US as compared to the WE. Significant Plaque formation was present in US 11 % vs. WE 10 % of all cases. The distribution of the cardiovascular risk factors may indicate that WE is in a process of catching up with disease. Given these results in an asymptomatic working environment, notably the elevated BMI in the US serious and aggressive interventions should be employed. In WE similar measures should be implemented as the differences are relatively small in IMTplus® values and cardiovascular risk factors.