Abstract 427: Quantification of Left Ventricular Function by Speckle Tracking Imaging in Heart Transplant Patients
Speckle tracking imaging is a new echocardiographic technique that allows a quantitative assessment of ventricular function. Normal values have been described for healthy population. There are no data available about normal values in heart transplant patients (HTx). Our aim was to assess values of 2D strain (2DS) and strain rate (SR) in healthy heart transplant patients with normal contractility at rest and without cardiac allograft vasculopathy (CAV), and to compare them with a control group (non-HTx).
Methods: 30 consecutive HTx recipients without CAV or acute rejection (mean age 53 years, 22 men, time post-HTx 56 months) and normal contractility at rest scheduled for echocardiography evaluation were included in the study. The control group included 10 healthy individuals with normal echocardiography (mean age 45 years, 6 men). Longitudinal global 2DS and strain rate (SR) were measured in 4, 2 and 3 chambers views in a 18 myocardial segment model.
Results: Ejection fraction (EF) was higher in HTx (HTx 72% vs non-HTx 65%, p = 0.002). In the speckle tracking analysis, from a total of 612 segments, 605 could be analyzed. Peak 2DS was significantly lower in HTX (HTx: −16.42±7 % vs non-HTx −21.22±4 %, p <0001). No differences were found in peak systolic SR (HTx: −1.262±0.5 s-1; non-HTx −1.281±0.3 s-1; p = 0.6).
Conclusions: Normal values of resting 2DS show significant difference between HTx and normal patients in spite of normal or higher EF evaluated by conventional wall-motion analysis. In the quantitative assessment of myocardial function, normal values of 2DS described in healthy patients can’t be applied to HTx.