Abstract 414: Impact of Aging on the Normal Right Ventricle: A Cardiovascular Magnetic Resonance Study
Background: Cardiovascular magnetic resonance (CMR) is considered the non-invasive gold standard for assessment of the right ventricle (RV). Age-specific CMR reference values for RV mass (RVM), end-diastolic volume (EDV), end-systolic volume (ESV), and stroke volume (SV) are of importance to differentiate between normal and pathologic states. We sought to characterize these age-specific RV parameters in a free living adult population using a modern CMR imaging sequence.
Methods: Cine steady state free precession CMR was performed on 1527 members of the Framingham Offspring Cohort. Of these, 852 (340 men, 512 women) subjects free of any history of hypertension and clinical cardiovascular disease and who had preserved global and regional LV systolic function were included in this analysis. Endocardial and epicardial RV borders were manually traced at end-diastole and endocardial borders at end-systole and a summation of discs method was applied. Results were indexed to body surface area (BSA). Subjects were stratified by age (≤55, 56 – 65 and ≥65 years) and sex. Trends with age were tested using ANOVA and between-sex comparisons for each age group used two-sample t-test.
Results: Data are summarized by sex and age-group in the Table⇓. For both sexes there was significant decline in RV EDV and ESV with advancing age. There was a decline in RV mass (p<0.001) with age in women, but not men.
Conclusion: RV anatomic parameters vary with age and gender in adults free of hypertension and clinical cardiovascular disease. Men have greater RV mass and volumes than women. In women, both RV volumes and mass decline with age whereas in men RV mass does not change with age. These data provide age and sex-based normative RV values for Caucasians.