Abstract 393: Diagnostic Accuracy of 320-slice Multi-Slice Computed Tomography in the Non-invasive Assessment of Obstructive Atherosclerosis
Objectives. Multi-slice computed tomography (MSCT) has been demonstrated as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-slice MSCT systems were introduced, with 16-cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-slice MSCT coronary angiography in patients with known or suspected CAD.
Methods. A total of 64 patients (34 male, mean age 61±16 years) underwent MSCT and conventional coronary angiography. All MSCT scans were evaluated for the presence of significant CAD (stenosis ≥ 50% luminal narrowing) by a blinded observer, and results were compared to quantitative coronary angiography (QCA).
Results. Four patients were excluded from analysis owing to non-diagnostic image quality. Sensitivity, specificity, positive and negative predictive values to detect significant CAD on segment basis were: 87%, 97%, 75% and 99%, respectively; on vessel basis 94%, 92%, 83%, and 97%, respectively and on a patient basis 100%, 88%, 92% and 100%, respectively.
Conclusion. The current study shows that 320-slice MSCT allows accurate non-invasive assessment of significant CAD.