Abstract 361: Global Systolic Dysfunction in Patients With Heart Failure and Normal Ejection Fraction
Purpose- Previous studies suggest normal torsion and circumferential strain preserve normal ejection fraction in presence of reduced longitudinal and radial strain in patients with heart failure and normal ejection fraction (HFNEF). We examined the myocardial deformations in a larger cohort with HFNEF.
Methods - Two-dimensional speckled echocardiography was performed in 113 (age:74±12) HFNEF patients with ejection fraction >50%, 176 (age:67±13) patients with HF and reduced ejection fraction (HFREF) and 60 (age:53±9) normal control subjects.
Results - Torsion (HFREF: 8.2±5.3°, HFNEF: 16.2±7.1°, control: 21.4±5.1°, P < 0.001), global circumferential strain (HFREF: 9.5±3.3, HFNEF: 20.7±5.0, control: 26.4±3.6, P < 0.001), global longitudinal and radial strains were significantly lower in both heart failure groups than in controls, and were depressed to a larger extent in HFREF patients than in those with HFNEF (both P < 0.001) after age adjustment. (Table 1⇓)
Conclusions - LV longitudinal, radial, and circumferential deformation, and torsion are all reduced in HFNEF but to lesser extent than in HFREF. Isolated diastolic dysfunction in HFNEF is uncommon.