Abstract 230: Phosphorus Concentration is Associated With Valvular and Annular Calcification: The Cardiovascular Health Study
Introduction: Mineral metabolism disturbances are common among older people and may have consequences for vascular and cardiac valve calcification. Associations of serum mineral metabolism markers with cardiac valve calcification have not been evaluated in a general population of older adults independent of kidney function.
Hypothesis: We hypothesized that higher serum phosphorus and parathyroid hormone levels, and lower vitamin D levels would be associated with valvular and annular calcification among participants in the Cardiovascular Health Study (CHS).
Methods: We measured serum levels of phosphorus, calcium, parathyroid hormone, and 25-hydroxyvitamin D among CHS participants who were free of cardiovascular disease at the 1992–1993 examination. Aortic valve sclerosis (AVS), mitral annular calcification (MAC), and aortic annular calcification (AAC) were identified by echocardiography during the 1994 –1995 examination. We quantified associations of mineral metabolism markers with AVS, MAC, and AAC using logistic regression models with adjustment for demographics and previously published risk factors including kidney function.
Results: There were 1,938 participants who completed mineral metabolism measurements and underwent echocardiography. Prevalences of AVS, MAC, and AAC were 49.5%, 39.2%, and 43.0% respectively. Greater serum phosphorus concentrations were associated with significantly greater risks of AVS (p=0.01), MAC (p=0.02), and AAC (p=0.02) (Table 1⇓). 25-hydroxyvitamin D and parathyroid hormone levels were not associated with valvular or annular calcification.
Conclusions: Greater serum phosphorus levels within the normal range are independently associated with valvular and annular calcification in a population-based cohort of older adults.