Abstract 207: Three-territory Whole-artery Coronary Imaging: Comparison Between Coronary 64-Slice Computed Tomography versus Intravascular Ultrasound
Background: Little is known about the accuracy of 64-MDCT-based (multi detector computed tomography) quantitative assessment of coronary lumen diameter and cross-sectional vascular area in comparison to intravascular ultrasound (IVUS).
Methods and Results: In a 64-MDCT based 3-vessel whole-artery analysis protocol, 70 vessels were imaged from 21 patients with known coronary disease (3.3 vessels per patient) and compared to IVUS examination performed within 72 hours. The 70 vessels were further divided into 641 subsegments of 4 mm each, and 10,466 MDCT cross-sections were compared to analysis of 5,972 IVUS cross-sections. The MDCT and IVUS measurements for lumen area and external elastic lamina (EEL) area were highly correlated (correlation coefficient 0.81 and 0.78 respectively; p<0.0001 for both), while the measurements for plaque plus media area and percent plaque burden were only moderately correlated (correlation coefficient 0.55 and 0.49 respectively; p<0.01 for both) (Figure⇓). Overall, the absolute difference between the 64-MDCT and IVUS measurements for lumen was negligible but with a wide dispersion of the differences. MDCT overestimated the EEL area, the plaque plus media area, and the percent plaque burden.
Conclusion: Our study shows that MDCT imaging significantly correlates with the gray-scale IVUS. These findings indicate that MDCT may be a useful non-invasive tool for the quantitative evaluation of lumen and plaque parameters.