Abstract P202: Comparison Between Initial Blood Examination Data and Neurological Outcome in Out-of hospital Cardiac Arrest Patients Treated With Hypothermia Therapy, From Multicenter Hypothermia Registry in Japan: J-PULSE- Hypo Registry
Background: Although mild hypothermia (MH) has neurological benefits for patients with return of spontaneous circulation (ROSC) after out-of-hospital ventricular fibrillation cardiac arrest, there are limited data about predictors of good neurological outcome in these patients.
Method: Three years (2005–2007) data were available for 281 patients treated with MH in the multicenter registry in Japan (J-Pulse-Hypo). We examined the relationship between initial blood examination data and neurological outcome. Primary end point of this study was favorable neurologic outcome (cerebral performance category (CPC) 1 and 2) rate at 30 days.
Result: According to neurologic outcome at 30 days, we divided all cases into two groups: the favorable outcome group (n=158 (CPC 1=143, CPC 2=15)) and the unfavorable outcome one (n=123 (CPC 3=29, CPC 4=36 CPC 5 or death=58)). Favorable outcome rate at 30 days was 56.2%. Among initial data of blood examinations, there were significant differences in hematocrit (HCT), potassium (K), lactate dehydrogenase (LDH), glucose (BS), pH, carbon dioxide (PaCO2), and base excess between the favorable and unfavorable outcome groups. By the multiple logistic regression analysis, HCT, LDH, BS, and PaCO2 were revealed as the independent predictors of 30 days favorable outcome in addition to age, witness of cardiac arrest, and ROSC before admission.
Conclusion: Anemia, high LDH, hyperglycemia, and hypercapnia on admission were significantly associated with poor neurological outcome even among patients treated with hypothermia therapy.