Abstract 5856: Postchallenge Hyperglycemia is an Independent Risk Factor for Left Ventricular Hypertrophy in Non-diabetic Hypertensive Patients
Background: The relationship between postprandial hyperglycemia and cardiovascular disease has been recently noticed. The present study was designed to investigate the association of plasma glucose and insulin during an oral glucose tolerance test (OGTT) with left ventricular (LV) hypertrophy in non-diabetic hypertensive subjects.
Methods: A total of 215 hypertensive patients (mean age, 62±11 years) with fasting plasma glucose of <110 mg/dL and hemoglobin A1c of <<26>5.8% were enrolled in this study. Plasma glucose and insulin levels were measured at 0, 30, 60, and 120 min during 75-g OGTT, and maximal plasma glucose (PGmax) was also determined. LV mass index was echocardiographically measured.
Results: In all subjects, plasma glucose levels at 60 and 120 min, but not at 0 or 30 min, were significantly correlated with LV mass index. In particular, PGmax was most closely correlated with LV mass index (r=0.24, P=0.0005). LV mass index had no significant correlation with insulin levels during OGTT or the homeostasis model assessment (HOMA) index, a parameter of insulin resistance. When subjects were divided into two groups by a level of PGmax (200 mg/dL), LV mass index and prevalence of LV hypertrophy (LV mass index >=125/110 g/m2, M/F) were significantly higher in subjects with high PGmax (n=67) than the others (n=148). Logistic regression analyses revealed that high PGmax was a significant predictor of LV hypertrophy (odds ratio 2.23, P=0.027), independently of age, sex, body mass index, blood pressure, fasting plasma glucose, hemoglobin A1c, and HOMA index.
Conclusion: Our findings indicate that postchallenge hyperglycemia is an independent risk factor for LV hypertrophy in hypertensive patients with normal fasting plasma glucose and hemoglobin A1c.