Abstract 5792: Lower Ankle-Brachial Index Associated With Lipid-Rich Coronary Plaques in Patient Underwent Elective Coronary Intervention: Integrated Backscatter Ultrasound Analysis
Background Association between low Ankle Brachial Index (ABI) and cardiovascular events were demonstrated. The aim of this study is to evaluate association between ABI and coronary plaque radiofrequency characterization by integrated backscatter ultrasound (IB-IVUS).
Methods From Jan.2006 to Dec. 2008 Total of 189 consecutive patients who underwent elective PCI following ABI measurements and IB-IVUS analysis were enrolled. The Color coded maps of tissue characteristics of each 1mm slice of target lesions were constructed and volume of each plaque components (calcification, fibrous and lipid core) was calculated. And percentage of lipid volume in the target lesion (% lipid; volume of lipid core/total plaque volume) was calculated.
Results ABI significantly correlated with lipid volume of target lesion (r= −0.19, p<0.05), but did not correlate with fibrous volume (r=0.09, P=0.2)(Figure⇓). ABI (r= −0.18, p<0.01) and HDL-cholesterol (r= −0.14, p<0.05) inversely correlated with %lipid. There was no significant association between %lipid and other clinical factors (age, gender, conventional risk factors, blood pressure, lipid-profile and HbA1c). In multiple regression analysis, ABI significantly associated with %lipid after adjusting for age, gender, prior revascularization of PAD (bypass surgery or angioplasty), systolic BP, LDL-cholesterol, HDL-cholesterol, triglyceride and HbA1c.
Conclusion Our present findings provide the first evidence that decrease of ABI may be associated with progression of lipid-rich coronary plaques. After adjustment of other clinical factors, ABI independently associated with lipid-rich coronary plaque of coronary stenosis.