Abstract 5620: Relationship Between Stroke Risk (CHADS2 Score) and C-reactive Protein in Patients With Non- Rheumatic Atrial Fibrillation
Background- CHADS2 score is used for the stroke risk stratification in patients with atrial fibrillation (AF). Although C-reactive protein (CRP) has been shown as a possible correlate of left atrial (LA) thrombus formation in patients with non-rheumatic AF (NRAF), the relationship between CHADS2 score and CRP is unclear.
Methods- A total of 165 patients with NRAF (105 male, age 71±10 years) who underwent transesophageal echocardiography (TEE) were enrolled and analyzed. Patients with prosthetic valve, aortic dissection and infectious disease were excluded from this study. The CHADS2 score was calculated based on a presence or absence of risk factors (Congestive heart failure, Hypertension, Age≥75years, Diabetes mellitus, Stroke or transient ischemic attack) as reported previously. Based on the CHADS2 score, study patients were grouped into low (0 to 1 score), moderate (2 to 3 score) and high (4 to 6 score) risk categories.
Results- Patients at low risk had significantly lower CRP levels than those at moderate or high risk (Low: 0.27±0.46 vs. Moderate: 0.40±0.56 vs. High: 0.93±0.85mg/dl, p<0.01). As expected, incidence of LA spontaneous echo contrast and LA thrombus by TEE increased with increasing CHADS2 score. Conclusion- In patients with NRAF, CHADS2 score is related to CRP and LA thrombus formation.