Abstract 5327: Circulating Leukocyte Telomere Length Reflects the Burden of Oxidative Stress and Inflammation in Patients With Acute Myocardial Infarction
Objectives: Recent data suggest that leukocyte telomere length (TL) may be a possible reliable marker in human-aging diseases and cardiovascular illness such as coronary artery disease (CAD) and heart failure. The main outcome of our study was to identify the possible correlation between TL and biomarkers of oxidative and inflammatory status. in patients with acute myocardial infarction (MI).
Materials and Methods: The TL was determined prospectively by quantitative Polymerase Chain Reaction method from circulating leukocytes of consecutive patients admitted <24 h in intensive care unit for an acute MI, as well as leukocyte expression of c-Fos, gene involved in cellular proliferation and oxidative stress. Left ventricular ejection fraction (LVEF) was assessed by echocardiography <3 days after admission.
Results: Among the 69 patients included in the study, mean age was 66±2 and 78% were male, and TL was 1.34±0.01. A negative correlation was found between leukocyte TL and age (r=−0.37, p=0.002), cFos gene expression (r=−0.46, p<0.001), logNT-proBNP (r=−0.30, p=0.019) and CRP (r=−0.29, p=0.018). In contrast, creatinine clearance (r= +0.30, p=0.02), and LVEF (r= +0.26, p=0.04) were positively correlated with TL. Leukocyte count was not related with TL (p=0.54). Age-adjusted TL was significantly reduced in male vs. women (p=0.001), and in patients with hypertension (p=0.023), family history of CAD (p=0.006), smokers (p<0.001), or clinical heart failure on admission (p=0.009). Backward multivariable linear regression analysis identified cFos (β =0.51, p<0.001), smoking (β =0.25, p=0.031) and prior CAD (β =−0.266, p=−0.011) as factors independently associated with LT (R2=0.43).
Conclusion: Our study suggests that in patients with acute MI, circulating leukocyte TL reflects increased oxidative stress and inflammation, while the independent influence of age is limited. Considering the relevance of these findings, definitive question is if telomere attrition is a primary cause or a consequence of the development of the illness, encouraging further studies in this field.