Abstract 5153: Platelet Activation and Inflammatory Response in Patients With Non-dipper Hypertension
Objective: We aimed to determine whether MPV and hs-CRP levels are elevated in non-dipper patients compared to dippers and healthy controls. In addition, we tried to find out if MPV and CRP are related to each other or not in non-dipper hypertensives.
Method: The total 126 patients study group included 86 patients with hypertension and 40 healthy subjects (16 male, mean age; 51±4) as control. Ambulatory blood pressure monitoring was performed for all patients. Hypertensive patients were divided into two groups; 46 dipper patients (18 male, mean age; 50±9) and 40 non-dipper patients (17 male, mean age; 53±11). Clinical baseline characteristics were similar between groups. We measured mean platelet volume in a blood sample collected in EDTA tubes and high-sensitive CRP was measured by using BN2 model nefelometer.
Results: Non-dipper patients demonstrated higher levels of MPV compared to dippers and normotensives (9.72±0.52 vs 9.38±0.33 and 8.92±0.42, p<0.05, respectively). High-sensitive CRP levels were also significantly higher in non-dippers compared to dippers and normotensives (4.9±1.7 vs 3.8±1.5 and 2.7±0.8, p<0.05, respectively). There was significant positive correlation between MPV and CRP levels (p=0.002, r=0.482) in non-dipper hypertensives.
Conclusion: Our results suggest that patients with non-dipping tend to have increased platelet activation and inflammatory response. Increased platelet activation and inflammatory response could contribute to increase the atherosclerotic risk in non-dipper patients compared to dippers.