2009 Charles T. Dotter Memorial Lecture—Cardiovascular Molecular Imaging of Gene and Cell Therapies
Regenerative medicine with the use of stem cells has appeared as a potential therapeutic alternative for many disease states. Numerous questions remain with regard to the viability and biology of transplanted stem cells in the living subject. Recent advances in molecular biology and imaging have allowed the successful noninvasive monitoring of transplanted stem cells in the living subject. I will review the different imaging strategies that can be adopted to study the viability and biology of transplanted stem cells. These include the use of multimodality reporter gene imaging (eg, fusion reporters), including clinical translation of such strategies. Use of these strategies will be critical as the different regenerative therapies are being tested for clinical use.