Studies in Intravascular Coagulation
IV. The Effect of Heparin and Dicumarol on Serum-Induced Venous Thrombosis
A method has been previously described whereby the infusion of canine serun and serum fractions rich in convertin, but essentially devoid of thromboplastin, prothrombin, ac-globulin and thrombin, initiates venous thrombosis in dogs at sites of partial or complete venous stasis far removed from the site of infusion. It has been suggested that the pathogenesis of venous thrombosis in various clinical states may be referable to local stasis combined with a transient increase in circulating convertin activity. The present study demonstrates that heparin is superior to dicumarol in inhibiting the evolution of such serum-induced intravascular thrombi in dogs.
- © 1955 American Heart Association, Inc.