In the article by Finley et al, “Arginine Vasopressin Antagonists for the Treatment of Heart Failure and Hyponatremia,” which appeared in the July 22, 2008, issue of the journal (Circulation. 2008;118:410–421), the following corrections should be made:
In tables 5 and 6, the n number of patients in the EVEREST trial should be 4133, as correctly reported in the text, not 4113.
In the second paragraph on page 414, the reference after the line “In a double-blind study conducted in 254 stable chronic HF patients (regardless of LV ejection fraction), 3 oral doses of tolvaptan (30 mg, 45 mg, or 60 mg) given daily for 25 days were compared with placebo administration” should be reference number 38, not 53.
In paragraph 3 of the section, “Effects on Renal Function” on page 418, the statement relative to tolvaptan’s effects on glomerular filtration rate is incorrect. The passage should read, “In an open-label, randomized, placebo-controlled, single-dose crossover study in patients with mild to moderate chronic HF designed to assess the effects of tolvaptan and furosemide on renal function and renal hemodynamics, 62 tolvaptan was found to increase urine output and renal blood flow. In comparison, furosemide increased urine output to a comparable degree but at the expense of electrolyte excretion (urinary sodium and potassium) and renal blood flow. Tolvaptan, furosemide, and placebo did not differ in respect to mean arterial pressure, glomerular filtration rate, or serum sodium and potassium 62.”
In the Tables of clinical trial results, randomized, placebo-controlled, phase II trials that studied conivaptan in patients with euvolemic or hypervolemic hyponatremia were omitted. The study published by Ghali et al (Ghali JK, Koren MJ, Taylor JR, Brooks-Asplund E, Fan K, Long LA, Smith N. Efficacy and safety of oral conivaptan: a V1a/V2 vasopressin receptor antagonist assessed in a randomized, placebo-controlled trial in patient with euvolemic or hypervolemic hyponatremia. J Clin Endocrinol Metab. 2006;91:2145–2152) should have been included in Table 4.
These changes have been made to the current online version of the article. The authors regret these errors.