Abstract 5670: Type1 ECG in V2 Lead is an Independent Predictor of Ventricular Fibrillation in Brugada Syndrome
Risk stratification of Brugada syndrome remains controversial. In 52 consecutive patients (males/Females 49/3 mean age42±3) with Brugada syndrome, we analyzed relationships between risk of ventricular fibrillation (Vf) and history of syncope, family history of sudden cardiac death, presence of paroxysmal atrial fibrillation (Paf), existence of SCN5A mutations and promoter haplotypes, parameters and type of Brugada type ECG in 12 leads ECG, degrees of ST-segment elevation in baseline and after pilsicinide challenge, late potential, parameters and induction of Vf in EPS. They had the history of Vf in 19, syncope in 10, and family history of sudden cardiac death in 14. The incidence of promoter Haplotype B (Vf (+) vs Vf (−), 61.1 % vs. 41.2 %), Paf (38.8% vs. 23.5%), and type1 in right precordial lead (V1 72.3% vs. 67.6% and V2 61.1 % vs. 20.5%) were significantly higher in the subjects with history of Vf than in those without Vf by univariate analysis (p<0.05). The other parameters were similar in the both groups. We found mutations of SCN5A in 9.6 % among the patients and three of them were de novo mutations (N782T, G1420P and L1988R). However the mutations of SCN5A were not the risk of Vf events. Multivariate logistic regression analyses revealed that the coved type in V2 lead (odds ratio 12.5; 95% confidence interval 11.9 –13.1; P=0.02) was the only independent predictor of Vf in Brugada syndrome.