Abstract 5668: Prevalence of Brugada Sign and Syndrome in Patients Presenting with Arrhythmic Symptoms at a Heart Rhythm Clinic in Singapore
Southeast Asia is described as an endemic area for Brugada syndrome. Southeast Asia, however, is a heterogeneous region; the prevalence of Brugada syndrome in Singapore is unknown. The aim of this study was to determine the prevalence of Brugada sign (Brugada-type ECG) and syndrome among patients who presented for evaluation of arrhythmic symptoms at a heart rhythm clinic of a tertiary hospital in Singapore. Patients who presented without a known diagnosis for evaluation of presyncope, syncope, and/or, palpitations between 2005 and 2007 were included in the study. The study criteria were met by 392 patients (mean age: 49.6 ± 19.1 years, 55.9% male). The 12-lead electrocardiograms of these patients were analyzed and clinical information was abstracted. Brugada sign was observed in 28 patients, and 12 patients were determined to have Brugada syndrome (mean age: 36.3 ± 15.4 years, 100% male), yielding a prevalence of 7.1% (95% CI, 4.8 –10.2) and 3.1% (95% CI, 1.6 –5.3), respectively. The prevalence rates of patients with Type 1, Type 2, and Type 3 Brugada signs were 4.8% (95% CI, 2.9 –7.5), 1.8% (95% CI, 0.7–3.6), and 0.5% (95% CI, 0.06 –1.8), respectively. Over a total of 30.4 person-years of follow-up, there were no appropriate shocks or sudden cardiac deaths among patients with Brugada sign or syndrome. Despite the higher prevalence of Brugada sign and syndrome in this study compared with previous studies from other countries, the prognosis of both was benign. Further population-based investigation is warranted to confirm these findings.