Abstract 4880: The Common Variant Rs9939609 In The FTO Gene Is Associated With Early-onset Myocardial Infarction
Background and objective Type 2 diabetes and increase in body mass index (BMI) are major risk factors for myocardial infarction. Recently the common variant rs9939609 in the fat mass and obesity-associated (FTO) gene was reported to associate with type 2 diabetes only through an effect on body mass index (BMI). In the present study we investigated whether rs9939609 variant in the FTO gene is directly associated with early-onset myocardial infarction.
Method The Italian genetic study of early-onset myocardial infarction is a nationwide prospective case-control study involving 1842 patients hospitalised for a first myocardial infarction before the age of 45 years, and 1842 healthy subjects matched for age, gender and geographical origin. The following baseline data were collected for each case and control: age, gender, family history, body mass index, smoking habits, hypertension, hypercholesterolemia, diabetes, cocaine use, physical activity and alcohol consumption. Genotyping was performed using a Sequenome MassARRAY platform.
Results The rs9939609 variant in FTO gene was significantly associated with early-onset myocardial infarction (odds ratio 1,25, 95% confidence interval 1.08 to 1.45; p=0.000015) with a multiplicative model of the effect. After adjusting for diabetes, BMI, hypercholesterolemia and smoking the rs9939609 risk allele was still significantly associated with early-onset myocardial infarction (odds ratio 1.20, 95% confidence interval 1.05–1.38; p=0.006), thus indicating that this variant has a direct effect on myocardial infarction, not mediated by BMI. As previously reported FTO genotype was also associated with an increase in BMI, more specifically the p-value of no association in the control group is equal to 0,01.
Conclusions The rs9939609 variant in the FTO gene was significantly associated with the risk of early-onset myocardial infarction and with the increase in BMI. The rs9939609 variant in the FTO gene directly influences the risk of early-onset myocardial infarction.