Abstract 4846: Long-Term Follow-Up in Patients with Tako-Tsubo Cardiomyopathy
This study sought to assess the long-term outcome of patients with Tako-tsubo Cardiomyopathy (TTC). TTC is a recently described acute cardiac syndrome of uncertain etiology and outcome. One-hundred and one consecutive patients (94 female; mean age 73±10 years; range: from 33 to 90 years) with a confirmed diagnosis of TTC by angiography were prospectively identified and included in the study. Primary end-points were: death, syndrome recurrence and hospitalization from any cause. Over a mean follow-up of 2.0±1.3 years, only 55 patients resulted free from symptoms or major events. Chest pain (n=7) and dyspnea (n=5) were also the more frequent reasons for the high rehospitalization rate (22%). Only one patient had a recurrence of TTC. During long-term follow-up, 11 patients died (7 from cardiovascular cause). The only independent predictor of death at Cox analysis was age (HR 1.159, 95% CI 1.047–1.283; p=0.005). The use of beta-blockers was associated with a trend towards lower mortality rate (8% vs 16%; p=0.098). However, chest pain recurrence (26% vs 6%; p=0.021) and hospitalization rate (34% versus 16%; p=0.06) were more frequent in patients with beta-blockers therapy than in those without. The recurrence of TTC is rare. While, recurrence of chest pain or dyspnea is common in TTC patients and frequently results in hospital admission. Mortality was mainly related to patient’s old age. The role of beta-blockers therapy in the long-term management of patients with TTC is still to be clearly defined.