Abstract 4731: Impaired Right Ventricular Contraction and Relaxation in Patients with Left Ventricular Hypertrophy and Preserved Left Ventricular Ejection Fraction Quantified by Speckle-Tracking Strain and Strain Rate Imaging
Background: It has not been fully investigated whether right ventricular (RV) contraction and relaxation were impaired in patients with left ventricular hypertrophy (LVH) and normal left ventricular ejection fraction (LVEF).
Methods: To quantify longitudinal RV function, 30 patients with hypertensive LVH (LVH group: mean age 59 ± 15 years, LVEF 64 ± 5 %), 25 patients with hypertrophic cardiomyopathy (HCM group: mean age 60 ± 14 years, LVEF 71 ± 10 %) and 50 age matched normal controls (Control group: mean age 56 ± 15 years, LVEF 65 ± 5 %) had echo-study with speckle-tracking strain and strain rate imaging (Vivid 7 and EchoPAC, GE Electronic) from apical 4 chamber view. RV peak systolic strain (PSS) and peak relaxation rate (PRR) were used as indices of global RV contraction and relaxation, respectively. RV fractional area change was also analyzed.
Results: Both PSS and PRR were significantly reduced in LVH group compared to Control group and were further impaired in HCM group (PSS: −20 ± 4 %* in LVH group, −17 ± 5 %*† in HCM group, and −23 ± 4 % in Control group, PRR: 0.96 ± 0.23 1/s* in LVH group, 0.75 ± 0.35 1/s*† in HCM group, and 1.21 ± 0.32 1/s in Control group, *p < 0.05 vs. Control group and †p < 0.05 vs. LVH group, respectively) whereas RV fractional area change failed to discriminate from normal to impaired RV function (48 ± 11 % in LVH group, 50 ± 10 % in HCM group, and 48 ± 7 % in Control group, p = NS vs. Control group and vs. LVH group, respectively).
Conclusion: Speckle-tracking strain and strain rate imaging quantified RV contraction and relaxation and revealed their abnormalities in patients both with hypertensive LVH and HCM with normal LVEF.