Abstract 4693: Osteoporosis Treatment Associated with Decreased Progression of Aortic Stenosis
A decline in bone mineral density has been reported to be associated with progression of aortic stenosis (AS). We hypothesized that osteoporosis treatment (OT) is associated with decreased progression of AS. We performed a retrospective chart review of patients with mild and moderate aortic stenosis from our echocardiographic database comparing 18 patients on OT (bisphosphonates, calcitonin or estrogen receptor modulators) to 37 patients not on OT. All patients had serial echocardiograms. Patients with mitral stenosis, aortic valve replacement, renal failure, calcium disorders, or LVEF<40% were excluded. Aortic valve area (AVA) was calculated using the continuity equation. There was no significant difference in age (mean of 82 years), gender (76% female), renal function, hypertension, statin use, diabetes or calcium level between the two groups. The mean baseline aortic valve area was 1.33 cm2 and was not significantly different between the two groups. After a mean of 2.4 ± 1.0 years, the mean annual change in AVA was −0.10 ± 0.18 cm2 in patients receiving OT and −0.22 ± 0.22 cm2 in those not on OT (p=0.025). There was a graded association between AS progression rate and OT (Figure⇓). Age, gender, hypertension, renal function and statin use were not significantly associated with change in AVA. In a relatively small population of patients, osteoporosis treatment is strongly associated with decreased progression of aortic stenosis. This association warrants investigation in a larger, prospective study.