Abstract 4558: Dynamic Right Ventricular Function Assessment by Real-Time 3D Echography in Combination with Semiautomatic Endocardial Detection in Adults with Corrected Tetralogy of Fallot: Comparison with Magnetic Resonance Imaging
Assessment of right ventricle (RV) function is fundamental in the follow-up of patients with repaired tetralogy of Fallot (ToF) because pulmonary regurgitation may lead to severe RV impairment and ventricular arrhythmias. To evaluate RV volume and ejection fraction (EF) in adult normal subjects and repaired ToF with 3D trans-thoracic echocardiography (3DE) and a semiautomatic border detection (SBD) algorithm (Tomtec). 14 healthy volunteers and 21 patients with repaired ToF (mean age 31± 14) were prospectively enrolled and underwent 3DE and cardiac magnetic resonance (CMR) imaging within the same hour to ensure similar loading conditions. Agreement between both methods when measuring EF, end-diastolic volume (EDV) and end-systolic volume (ESV) was evaluated using Bland-Altman analysis. EF, ESV and EDV were 45.5 ± 6.9 % with 3DE and 47.8ml ± 6.7 with CMR, 156ml ± 59 and 163.5ml ± 54.6, and 86.4ml ± 38.2 and 86.6ml ± 37.5, respectively. Correlations between 3DE and MRI for EF, EDV and ESV were 0.69, 0.94, and 0.94, respectively. Intra-class correlation coefficients (ICC) for EF, EDV and ESV were 0.65, 0.93 and 0.93. ICCs were slightly higher for EF and ESV in healthy volunteers than in repaired ToF.
Conclusion: 3DE combined to a semi-automated quantification software is a reliable tool in the assessment of RV, especially in patients with repaired ToF.