Abstract 4502: Aortic Valvular Calcification Predicts Restenosis after Implantation of Drug-Eluting Stents
In the drug-eluting stent (DES) era, restenosis rate of the follow-up period after percutaneous coronary intervention (PCI) has been dramatically reduced. However, restenosis still occur in some case in usually clinical fields. The present study investigated the potential relationship between aortic valve calcification (AVC) and angiographical restenosis at follow-up after DES implantation. We prospectively performed echocardiography before elective PCI with DES implantation in consecutive 251 patients with 428 lesions. Angiographic follow-up was scheduled between 6 and 8 months after PCI. Restenosis at follow-up was defined as a diameter stenosis ≥50% by measuring quantitative coronary angiography. Of the patients enrolled into the study, 100 patients (39.8%) had AVC. The angiographical restenosis rate at follow-up period was 17.4% in patients with AVC and 5.5% in patients without AVC [odds ratio (OR) 3.65; 95% Confidential interval (CI) 1.87–7.12, P = 0.0001]. After multivariate adjustment including covariates related to atherogenecity, AVC (OR 3.46, 95%CI 1.31–9.12, p=0.012), lesion length (OR 1.26, 95%CI 1.11–1.43, p=0.0004) and hemodialysis (OR 3.22, 95%CI 1.14 –9.08, p=0.026) remained independent predictors for restenosis after implanting DES. As to quantitative coronary angiography, late loss and percent diameter stenosis at follow-up were significantly higher in the AVC group than in the non-AVC group (Table⇓). AVC provides predictive information regarding DES implantation. Results of quantitative coronary angiography.