Abstract 4483: Long-Term Clinical Outcomes of 233 Patients who Presented with Definite/Probable Stent Thrombosis
Stent thrombosis (ST) is the most concerning adverse outcome of drug-eluting stent (DES) placement. Clinical outcomes of patients experiencing definite and definite/probable ST by the Academic Research Consortium definitions, among the 9535 patients undergoing unrestricted percutaneous coronary intervention (PCI) with DES since April 2003, were examined. Clinical outcomes up to 3 years following DES implant of the patients with definite or probable ST were compared to those without ST. Baseline demographics were similar. The population was 65.7% male with a mean age of 63.7 years. 104 patients presented with 109 definite ST events. 233 patients were adjudicated to have experienced definite or probable ST events, 50 due to unexplained death within 30 days of DES implantation and 79 due to target vessel myocardial infarction with unknown culprit. Outcomes in both these groups were uniformly poorer with a much higher incidence of death, Q-wave myocardial infarction, and target vessel revascularization up to 3 years when compared to patients who did not experience definite or probable ST. (Table⇓) DES ST is an infrequent, but at 3 years 2/3 of the patients with DES ST are dying and the remaining are experiencing high morbidity.