Abstract 4004: Seasonal Variation in the Onset of Tako-Tsubo Cardiomyopathy
Aim of this study is to verify the hypothesis of a seasonal variation in the occurrence of Tako-tsubo cardiomyopathy (TTC). We included 78 consecutive pts (76 F, mean age 69.5 yrs), observed from 2002 to 2008 at the Tako-Tsubo Cardiomyopathy Italian Network (TIN) Centers, and that fulfilled the following diagnostic criteria for TTC:
transient akinesia/diskinesia beyond a single major coronary artery vascular distribution;
no angiographic evidence of significant coronary artery disease;
new electrocardiographic changes;
absence of intracranial bleeding, pheochromocitoma, myocarditis or hypertrophic cardiomyopathy.
The day of symptom onset was categorized into four three-month intervals for seasonal analysis, and the distribution was tested for uniformity by the χ2 test goodness of fit. A seasonal pattern, characterized by a highly significant peak in summer (χ2=51,82, p<0.0001), was found (figure⇓). Our data indicate a summer prevalence in the onset of TTC. This circannual rhythm is opposite to the trend detected in acute myocardial infarction and might be related with the summer peak of cathecolamine levels already documented in healthy women.