Abstract 2941: Routine Laboratory Results And One-year Mortality Risk Following Hospitalization With Acute Decompensated Heart Failure
Background: Various parameters are capable of predicting prognosis in patients with decompensated heart failure (HF). This study evaluated the relationship between routine admission laboratory tests results, patient characteristics and one year mortality of patients admitted for decompensated HF.
Methods: All patients with a principal diagnosis of heart failure (AMI excluded) admitted to seven major hospitals during years 2002–2005 were enrolled. Data on co-morbid conditions, medications, laboratory findings, in-hospital management were assessed. The primary end-point was all cause one year mortality.
Results: 8,246 patients were included into the study cohort. One year mortality rate 28.7% and was associated with patients’ age, comorbidities and routine admission laboratory results. Three dichotomized abnormal laboratory results with highest hazard ratio for one year mortality were identified and included into survival analysis- hypoalbuminaemia (<3.5 g/dL) found in 36.3% (hazard ratio [HR] 1.76, 95%CI 1.60–1.97), hyponatremia (< 136 meq/L) found in 22.0% of patients (HR 1.65, 95%CI 1.48–1.85) and elevated blood urea (≥ 3 mg/dL) found in 70.3% (HR 1.51, 95%CI 1.32–1.73). A prediction tool with one point assigned for each abnormal result was capable of discriminating from 11.6% to 55.6% in one year mortality rate between patients with a score of 0 (1,477 patients) and a score of 3 (544 patients).
Conclusions: We have demonstrated that few abnormal routine laboratory results upon admission with HF are independent predictors of one year mortality. This small panel of routine admission laboratory tests can risk-stratify patients hospitalized with decompensated HF.