Abstract 2795: Traditional Risk Factors & Coronary Plaque Composition Assessed by Non Invasive CT Angiography in Asymptomatic Individuals
Objective: Although prior studies have shown that traditional cardiovascular (CV) risk factors are associated with the burden of coronary atherosclerosis, less is known about the relationship of risk factors with coronary plaque sub-types. Coronary computed tomography angiography (CCTA) allows an assessment of both, total disease burden and plaque characteristics. In this study, we investigate the relationship between traditional CV risk factors and coronary plaque sub-types in a group of asymptomatic individuals.
Methods: The study population consisted of 931 asymptomatic Korean subjects (48±9 years; 61% were males) free of known CV disease who underwent 64-slice CCTA as part of a health screening evaluation. We analyzed plaque characteristics on a per-segment basis according to the modified AHA classification. Plaques occupied by calcified tissue more than 50% of the plaque area were classified as calcified, with <50% calcium as mixed, and plaques without any calcium as non-calcified.
Results: A total of 105 (11%) subjects had coronary plaque while 826 (89%) had no identifiable disease. Table 1⇓ illustrates the association between the individual risk factors and plaque sub-type using multivariable logistic regression analysis, with all risk factors adjusted simultaneously. Increasing age and male sex, two of the strongest known CV risk factors, were more strongly associated with calcified and mixed plaque as compared to non-calcified plaque. LDL-C and hypertension were only significantly associated with mixed and calcified plaques, respectively. Smoking was most strongly associated with the presence of non-calcified plaques.
Conclusion: Our study shows that different cardiovascular risk factors are associated with burden of different plaque sub-types in asymptomatic subjects. Future investigations should focus on whether specific risk factors, and thus plaque sub-type, are associated with a differential CV outcome. Relationship between traditional risk factors and coronary plaque sub-types