Abstract 2717: Brain Mammillary Body Volumes are Diminished in Heart Failure
Emotional and cognitive abnormalities, including memory deficits, are common in heart failure (HF). Mammillary bodies in the brain play essential roles in spatial and short-term memory processing, but have not been examined in persons with this diagnosis. We assessed brain mammillary body volumes in 17 HF (age 54.4 ± 8.1 years; LVEF 0.28 ± 0.07; all NYHA class II) and 50 controls (age 50.6 ± 7.0 years). Two high-resolution T1-weighted image volumes were collected with a 3.0 Tesla MRI scanner, averaged, reoriented into common space, and oversampled. Mammillary volumes were manually outlined, and left, right, and combined volumes were calculated and compared between groups. Volumes were significantly reduced on both sides in HF (right=79.91 ± 19.30mm3; left=79.09 ± 17.28mm3) compared to controls (right=96.71 ± 18.19mm3; left = 102.19 ± 18.45 mm3; p <0.003) even after controlling for age, gender, and intracranial volume (figure⇓). Volume loss in the mammillary bodies may contribute to spatial and short-term memory deficits in HF. The pathological processes contributing to volume reduction are unclear, but may include excitotoxic injury accompanying hypoxic/ischemic processes in pathologic HF perfusion and breathing, thiamine deficiency, and/or nutritional mal-absorption in the condition.