Abstract 2631: Nonfasting Triglycerides and Risk of Ischemic Stroke in the General Population
Background: The role of triglycerides in the risk of ischemic stroke remains controversial. Recently, a strong association was found between elevated levels of nonfasting triglycerides, which indicate the presence of remnant lipoproteins, and increased risk of ischemic heart disease. We tested the hypothesis that nonfasting triglycerides predict ischemic stroke in the general population.
Methods: We included 13,956 Danish men and women aged 20 –93 years from The Copenhagen City Heart Study. During 31 years of 100% complete follow-up, 1529 developed ischemic stroke.
Results: Cumulative incidences for ischemic stroke increased with increasing levels of nonfasting triglycerides (log-rank trend p=0.001). There was a stepwise increase in risk of ischemic stroke with increasing levels of nonfasting triglycerides, with no evidence of a threshold effect for both men and women (Figure⇓). Also, in men and women with a previous ischemic stroke vs. controls, nonfasting triglycerides and remnant cholesterol levels were elevated (both p=0.001).
Conclusions: Nonfasting triglycerides ≥5mmol/L (≥443 mg/dL) predict, respectively, 3 and 4 fold increases in risk of ischemic stroke in men and women in the general population.