Abstract 2514: Endovascular Imaging Causes Significant But Temporary Endothelial Injury
Coronary Imaging e.g. IVUS and OCT to assess vascular size, plaque morphology and composition are useful tools in clinical trials as well as in routine practice. It is unclear whether imaging catheters induce acute endothelial cell damage (ECD) and how this heals over time.
Methods. Normal porcine coronary arteries were subjected to intravascular imaging (Raman, IVUS, OCT), guidewire-only placement or no manipulation (control). ECD was assessed acute or at 5 days (chronic) with an Evans Blue dye-exclusion test and planimetry followed by scanning electron microscopy (SEM).
Results. Acute injury (% staining of the area exposed to imaging) was considerable, but similar for the 3 imaging catheters. Guidewire-only induced less ECD. One-way ANOVA showed that only OCT- and RAMAN induced more ECD than control. Analysis with SEM showed that staining was associated with either EC denudation or injured but present EC. At 5 days staining was reduced to background levels.
Conclusion. Vascular imaging and guide wire manipulation both induce acute ECD, but this injury heals within 5 days following imaging. Planimetry of endothelial injury