Abstract 2472: Aortic Stiffness: A Reversible Marker of Cardiovascular Risk in Primary Hyperparathyroidism?
Patients with primary hyperparathyroidism (PHPT) are at increased risk of cardiovascular death. We investigated whether aortic stiffness, an early marker of arteriosclerosis, is increased in PHPT (Study A), and whether it improves after parathyroidectomy (Study B). Study A: 19 patients with PHPT (age 57±11 years, blood pressure 149/89 mmHg) and 38 age-, sex- and blood pressure-matched control subjects underwent aortic pulse wave velocity (PWV) determination with an applanation tonometry device (Sphygmocor). Aortic PWV was significantly higher in PHTP patients than in control subjects (11.3±2 vs 9.7± m/s, p<0.01). Study B: 11 of the PHTP patients underwent surgical parathyroidectomy and were reexamined 4 weeks after surgery. As expected, surgery was accompanied by a reduction in serum calcium (from 11.4±1 to 8.9± mg/dL, p<0.001) and parathyroid hormone level (from 415±472 to 31±27 pg/mL, p<0.001). Aortic PWV decreased after surgery (from 10.6±2 to 9.2±2 m/s, p=0.004), and the difference was independent from changes in blood pressure. Primary hyperparathyroidism is associated with increased aortic stiffness, which improves after parathyroidectomy. We demonstrate that aortic stiffness may improve upon removal of hyperparathyroidic stimuli.